HTRF - Eif2 alpha phospho-s52 - 500 tests 1 Kit

Alternative ELISA et WB, plus simple, plus rapide, très sensible, facilement miniaturisable / automatisable et peu onéreuse.

The phospho-EIF2 alpha assay is designed for the cell-based quantitative detection of Ser52 phosphorylation on EIF2 alpha. In NASH, lipid accumulation in hepatocytes (steatosis) induces oxidative and ER stresses, resulting in an increase in Phospho-EIF2alpha (Ser52). Phosphorylated EIF2alpha reduces global protein synthesis and activates ATF4 (Activating Transcription Factor 4), which modulates the expression of specific genes involved in the regulation of metabolism, nutrient uptake, the redox status of cells, and apoptosis.