HTRF - Eif2 alpha total - 500 tests 1 Kit

Alternative ELISA et WB, plus simple, plus rapide, très sensible, facilement miniaturisable / automatisable et peu onéreuse.

The Total EIF2 alpha cellular assay monitors total EIF2 alpha and is used as a normalization assay with the phospho-EIF2 alpha kit. In NASH, lipid accumulation in hepatocytes (steatosis) induces oxidative and ER stresses, resulting in an increase of Phospho-EIF2alpha (Ser52). Phosphorylated EIF2 alpha reduces global protein synthesis and activates ATF4 (Activating Transcription Factor 4), which modulates the expression of specific genes involved in the regulation of metabolism, nutrient uptake, the redox status of cells, and apoptosis.