HTRF - Hmgb - 500 tests 1 Kit

Alternative ELISA et WB, plus simple, plus rapide, très sensible, facilement miniaturisable / automatisable et peu onéreuse.

In the nucleus, ​High-mobility group box 1 (HMGB1)  interacts with DNA and histones to determine chromatin structure. Once released, HMGB1 acquires a new role as an alarmin or a damage-associated molecular pattern (DAMP) and is capable of initiating a state of inflammation by binding TLR4 and promoting the production of cytokines. Necrosis, pyroptosis,  and apoptosis are mechanisms of regulated cell death that have been shown to lead to the release of different forms of HMGB1. In pyroptosis, HMGB1 is released together with IL-1b and IL-18. HMGB1 is implicated in the pathology of several auto-immune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).