HTRF - Human h232 sting binding - 500 tests 1 Kit

Alternative ELISA et WB, plus simple, plus rapide, très sensible, facilement miniaturisable / automatisable et peu onéreuse.

A fast and easy way to identify new binders to human H232 STING. Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173), is a protein playing a major role in innate immunity. The H232 variant is found in 13.7% of the world population. Upon intracellular cytosolic DNA release from pathogens such as viruses and bacteria, 2’-3’cGAMP binds to STING protein and triggers the secretion of type 1 interferon.  However, the H232 variant is known to poorly bind 2'-3'cGAMP and other natural dinucleotides. The quest for molecules that are effective against all genetic variants has become crucial to modulate immunity in autoinflammatory diseases.