HTRF - Il12/il12rb1 binding - 500 tests 1 Kit

Alternative ELISA et WB, plus simple, plus rapide, très sensible, facilement miniaturisable / automatisable et peu onéreuse.

Also known as NKSF (natural killer cell stimulatory factor) and CLMF (cytotoxic lymphocyte maturation factor), IL12 is produced by macrophages and B cells. Along with IFN gamma, IL12 promotes the differentiation of naïve T cells into TH1 cells, which in turn release IFNg and IL2. Because of its effects on TH1 induction, IL12 is strongly linked to autoimmunity. IL12 is a heterodimer of p35 and p40 which binds the heterodimeric IL12Rβ1, IL12Rβ2 complex. The Human IL12/IL12Rβ1R assay is highly specific for IL12/IL12Rβ1 and hence is especially suitable for the discovery and characterization of anti p40 antibodies.