HTRF - Il6/il6r binding - 500 tests 1 Kit

Alternative ELISA et WB, plus simple, plus rapide, très sensible, facilement miniaturisable / automatisable et peu onéreuse.

IL6 is an inflammatory cytokine involved in various biological processes, including autoimmune diseases and cancers. It is produced by many cell lineages, including stromal cells, hematopoietic cells, epithelial cells, or muscle cells. IL6 binding to the membrane receptor IL6R induces receptor dimerization, and the activation of receptor-associated kinases (JAK1, JAK2, and Tyk2) which phosphorylate the receptor, leading to pathway stimulation. Anti-IL6 therapies have been developed for the treatment of various rheumatic diseases, as well as cytokine release syndrome.