HTRF - Mkk4 phospho-s257 - 500 tests 1 Kit

Alternative ELISA et WB, plus simple, plus rapide, très sensible, facilement miniaturisable / automatisable et peu onéreuse.

This HTRF cell-based assay conveniently and accurately quantifies phosphorylated MKK4 (Mitogen-Activated Protein Kinase Kinase 4) at Ser257. Phosphorylation of MKK4 on Serine 257 is induced by various MKKKinases such as TAK1, Tpl2, or ASK1, in response to cellular stresses and proinflammatory cytokines. Once phosphorylated, MKK4 preferentially triggers the activation of JNK, which regulates a range of biological processes implicated in tumorigenesis, neurodegenerative disorders, and fibrosis.