Atp6v0e (human) recombinant (full l enght protein gst tag) 25 µg

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunités enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunitéss, two G subunitéss plus the C, D, E, F, and H subunitéss. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunitéss: a, c, c', c”, and d. Additional isoforms of many of the V1 and V0 subunités proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunités. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq]