Cox6a1 (human) recombinant (full le nght protein gst tag) 10 µg

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunitéss encoded by mitochondrial genes and multiple structural subunitéss encoded by nuclear genes. The mitochondrially-encoded subunitéss function in the electron transfer and the nuclear-encoded subunitéss may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunités VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunités VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. [provided by RefSeq]