Nfya (human) recombinant (partial p rotein gst tag) 10 µg

The protein encoded by this gene is one subunités of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunités A associates with a tight dimer composed of the B and C subunitéss, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunités, suggesting a role as the regulatory subunités. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq]