Prkar1a (human) recombinant (full l enght protein gst tag) 10 µg

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunitéss. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunitéss bound to four cAMP and two free monomeric catalytic subunitéss. Four different regulatory subunitéss and three catalytic subunitéss have been identified in humans. This gene encodes one of the regulatory subunitéss. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunités of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]