Prkar2b (human) recombinant (partia l protein gst tag) 25 µg

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunitéss. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunitéss bound to four cAMP and two free monomeric catalytic subunitéss. Four different regulatory subunitéss and three catalytic subunitéss have been identified in humans. The protein encoded by this gene is one of the regulatory subunitéss. This subunités can be phosphorylated by the activated catalytic subunités. This subunités has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunités may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunités may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq]