Psmb7 (human) recombinant (partial protein gst tag) 25 µg

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunitéss; 2 rings are composed of 7 alpha subunitéss and 2 rings are composed of 7 beta subunitéss. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunités in the proteasome. Expression of this catalytic subunités is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunités. This subunités is not present in the immunoproteasome and is replaced by catalytic subunités 2i (proteasome beta 10 subunités). [provided by RefSeq]