Psmb8 (human) recombinant (partial protein gst tag) 25 µg

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunitéss; 2 rings are composed of 7 alpha subunitéss and 2 rings are composed of 7 beta subunitéss. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunités. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunités 3 (proteasome beta 5 subunités) in the immunoproteasome. Proteolytic processing is required to generate a mature subunités. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunités. [provided by RefSeq]