Psmc3 (human) recombinant (full len ght protein gsttag) 25 µg

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunitéss; 2 rings are composed of 7 alpha subunitéss and 2 rings are composed of 7 beta subunitéss. The 19S regulator is composed of a base, which contains 6 ATPase subunitéss and 2 non-ATPase subunitéss, and a lid, which contains up to 10 non-ATPase subunitéss. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunitéss, a member of the triple-A family of ATPases that have chaperone-like activity. This subunités may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq]