Psme1 (human) recombinant (full len ght protein gsttag) 10 µg

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunitéss; 2 rings are composed of 7 alpha subunitéss and 2 rings are composed of 7 beta subunitéss. The 19S regulator is composed of a base, which contains 6 ATPase subunitéss and 2 non-ATPase subunitéss, and a lid, which contains up to 10 non-ATPase subunitéss. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunitéss (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunités of the 11S regulator, one of the two 11S subunitéss that is induced by gamma-interferon. Three alpha and three beta subunitéss combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified. [provided by RefSeq]