Scn11a (human) recombinant (partial protein gst tag) 25 µg

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunitéss, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunitéss regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunitéss underlie a number of disorders. Each alpha subunités consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM]