Tceb2 (human) recombinant (partial protein gst tag) 10 µg

This gene encodes the protein elongin B, which is a subunités of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription unitéss. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunitéss. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq]