Recombinant Human CD155-Fc Chimera (carrier-free) 10 µg

CD155 is a transmembrane adhesion protein that belongs to the immunoglobulin superfamily. It possesses three immunoglobulin-like domains, a transmembrane domain, and the intracellular domain. CD155 is encoded by eight exons and differential mRNA splicing results in four isoforms named PVRα, PVRβ, PVRγ, and PVRδ. The alpha and delta isoforms are membrane attached and the beta and gamma are soluble. The isoform PVRβ has a partial sequence and PVRγ lacks exon six, which codifies the transmembrane domain. The extracellular domain is identical in all the isoforms and binds to the polio virus; therefore, the soluble forms compete with the membrane attached isoforms for the binding of the virus. PVR/CD155 is expressed in multiple tumors such as colorectal, gastric, multiple myeloma, myeloid leukemias, ovarian cancers, and melanoma. CD266 is expressed in CTL and NK cells and binds to CD155 expressed in cancer cells; therefore, CD226 might contribute in the immunity against CD155+ cancer cells. High levels of soluble forms of CD155 (PVRβ and PVRγ) have been detected in the serum of patients with cancer; thus, sCD155 might be a useful biomarker in cancer progression.;