Recombinant Human CD47-Fc Chimera (carrier-free) 100 µg

CD47 (Cluster of differentiation 47), also known as integrin-associated protein (IAP), is a about 50 kD glycosylated protein belonging to the immunoglobulin superfamily. It is a ubiquitously expressed integral membrane protein with a single IgV-like domain at its N-terminus, five membrane-spanning regions, and an alternatively spliced cytoplasmic C-terminus. CD47 was first identified as a protein involved in β3 integrin-mediated signaling in leukocytes, but its known to interact with SIRPα (signal regulatory protein-alpha), TSP-1 (thrombospondin-1), and other integrin members to regulate cell migration, axon extension, cytokine production, and T cell activation. CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. These interactions function as a negative immune checkpoint to prevent the macrophage-mediated clearance of healthy CD47-expressing cells. CD47 also associates in cis with Fas on T cells and enhances Fas-mediated apoptosis. CD47 and Fas ligation promotes T cell anergy and dampens Th1 immune responses.;