Recombinant Mouse CCL3 (MIP-1 Alpha) (carrier-free) 10 µg

CCL3 is a chemokine belonging to the CC chemokine family. CCL3 is involved in activation and recruitment of lymphocytes, monocytes, and granulocytes during acute inflammation. In addition to regulating leukocyte migration, CCL3 enhances IFN-γ secretion from activated T cells and thus induces Th1 response. Moreover, CCL3 has been reported to be involved in susceptibility of HIV infection and disease progression of AIDS. Also, CCL3 expression is increased during atherosclerotic lesion formation in mice, and CCL3 deficiency inhibits atherosclerotic lesion development by affecting neutrophil accumulation. Previous data has shown that CCL3 uses CCR1 to promote neutrophil recruitment in OVA-challenged, immunized mice.;